GFR 肌酐清除率 Cockcroft

🫘 Cockcroft-Gault Creatinine Clearance Calculator

Estimate creatinine clearance with the Cockcroft-Gault equation from age, weight, sex and serum creatinine, then normalise it to 1.73 m² using the body surface area derived from the entered height; the estimate still used for many renal drug dose adjustments.

📐 计算公式与说明

CrCl = (140 − 年龄) × 体重 / [72 × (血肌酐 µmol/L ÷ 88.4)] × 性别系数(女 0.85)
女性 ×0.85
体表面积归一:BSA = 0.007184 × 体重(kg)^0.425 × 身高(cm)^0.725(DuBois),归一值 = CrCl × 1.73 ÷ BSA
体重口径可选:实际体重 TBW(默认)|理想体重 IBW = 50/45.5 + 0.91×(身高cm − 152.4)|校正体重 ABW = IBW + 0.4×(TBW − IBW);BMI ≥30 且用实际体重时提示改用 IBW/ABW,否则 CrCl 会被高估。

用于药物剂量调整。

Formula & Standard References

Item Formula / Note Source / Standard
Equation origin creatinine clearance uses age weight and creatinine with a sex correction Cockcroft & Gault 1976, Nephron
Difference from filtration the equation estimates clearance not filtration and they converge when function is normal KDIGO 2012, CKD evaluation
Drug dosing label dose adjustments often rely on this equation and are not interchangeable WHO Model Formulary

📚 深度解析:肌酐清除率 Cockcroft-Gault

💡 常见使用场景

方法
算法(标准 Cockcroft-Gault):CrCl = (140−年龄)×体重(kg) ÷ (72×SCr_mg/dL) × (女×0.85),单位 mL/min;体表面积归一值 = CrCl×1.73÷BSA,BSA 按输入身高用 DuBois 式(0.007184×体重^0.425×身高^0.725)计算,不再假定固定身高。
算例(标准值)
例1(50 岁、70kg、血肌酐 80µmol/L=0.905mg/dL、男):CrCl = (140−50)×70 ÷ (72×0.905) = 96.7 mL/min。例2(65 岁、60kg、120µmol/L=1.357mg/dL、女):CrCl = (140−65)×60 ÷ (72×1.357) × 0.85 = 39.1 mL/min(偏低,提示肾功能减退)。

❓ 常见问题(FAQ)

CrCl 和 eGFR 区别?
CrCl 由 Cockcroft-Gault 估算、单位 mL/min,常用于给药;eGFR 由 CKD-EPI 估算、体标化 mL/min/1.73m²,常用于 CKD 分期。两者接近但不等同。
为什么还有体表面积归一值?
按 1.73 m² 归一后可与其他体标化指标比较;本页按你输入的身高计算 BSA,身高不同归一值会随之变化(矮个患者会偏高、高个患者会偏低)。Cockcroft-Gault 与 eGFR 不可互换,肾剂量调整请遵说明书。