新生儿黄疸(小时胆红素)曲线

Neonatal Jaundice (Hour-Specific Bilirubin) Nomogram

Plot hour-specific serum bilirubin for neonatal jaundice risk.

📖 Source: Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999;103(1):6-14. | Bhutani hour-specific nomogram · 40th / 75th / 95th percentile zones (low, low-intermediate, high-intermediate, high risk) · guides discharge follow-up
📐 工作原理与说明
新生儿黄疸(Bhutani 曲线 + 光疗/换血阈值)
高危组:胎龄 <38 周 或 存在危险因素;阈值按高危/低危两条曲线插值
风险分区:胆红素 ≥换血阈值 → 换血治疗区;≥光疗阈值 → 光疗阈值区;距光疗 <2 mg/dL → 接近阈值
百分位分区:≥95th 高危区|75-95th 中高危|40-75th 中低危|<40th 低危
换算:μmol/L ÷ 17.1 = mg/dL

Plot hour-specific serum bilirubin for neonatal jaundice risk.: computes and outputs results from the input parameters.

⚠️ 本工具为新生儿黄疸风险分层辅助工具,仅供医学人员快速估算,不替代临床检查与医生决策。危重/高风险患儿请立即按新生儿规范处理。

Bhutani 列线图风险分区(按日龄百分位)

  • ≥95 百分位 → 高危区(红):需密切监测/干预
  • 75-95 百分位 → 中高危区(橙):建议随访 24h
  • 40-75 百分位 → 中低危区(黄):可随访
  • <40 百分位 → 低危区(绿):风险低
  • 光疗/换血阈值随胎龄与高危因素降低。本工具采用 AAP 2022 简化阈值。

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Formula & Standard References

Item Formula Source-Standard
Nomogram use The hour-specific nomogram predicts the risk of significant hyperbilirubinemia Bhutani VK et al. Pediatrics 1999;103:6-14 (hour-specific bilirubin nomogram)
High-risk zone Values in the high-risk zone require close monitoring and timely intervention Bhutani VK et al. Pediatrics 1999;103:6-14 (hour-specific bilirubin nomogram)
Phototherapy / exchange thresholds AAP 2022 simplified thresholds stratified by postnatal hours and gestational age/risk factors Kemper AR et al. Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation. Pediatrics 2022;150(3):e2022060643
Conversion rule 1 mg/dL equals about 17.1 micromol/L for consistent plotting 通用换算系数(胆红素分子量 584.7 g/mol:1 mg/dL ≈ 17.1 μmol/L)

📚 深度解析:新生儿黄疸小时胆红素曲线

💡 常见使用场景

48h 14 mg/dL
Bhutani 约 40–75 分位;低风险光疗阈值≈12 mg/dL → 超标需光疗。
高危更严
胎龄<38 周或高危,光疗阈值降至≈10 mg/dL,列线图整体左移。

❓ 常见问题(FAQ)

与 neonatal-jaundice 关系?
同属小时胆红素曲线,本键为旧 slug,算法一致。
百分位含义?
同小时龄 TSB 在人群分布位置,越高越接近光疗线。